Mercedes-Benz · Large cars · Plug-in hybrid
Mercedes-Benz S-Class Plug-in hybrid: MPG and annual fuel cost, 2025
The Mercedes-Benz S-Class Plug-in hybrid was last rated in the data for model year 2025, at 23 MPG combined.
- 23MPG combined
- $3,550a year in fuel
- 106g/mile CO2
Where it stands
Across every class it is tied for 13th of 21 plug-in hybrid models, in the lower half.
A plug-in hybrid can run on its battery for a distance and then on fuel. The MPG, fuel cost and CO2 figures on this site are for running on fuel with the battery depleted, so a driver who charges often will use less fuel than shown.
Fuel cost and CO2
At 15,000 miles a year with 55% of them in the city, with premium gasoline at $5.48 per gallon, the annual fuel bill of the most efficient version is about $3,550.
Tailpipe CO2 is 106 g/mile for the most efficient version.
Rated versions
In the city the most efficient version is rated 20 and on the highway 29, 9 better on the open road. 2 versions are rated for 2025. The most efficient, S580e 4matic: 3.0 L, 6 cyl hybrid, Automatic 9-spd, AWD, gets 23 MPG; the least efficient listed, AMG S63 E Performance: 4.0 L, 8 cyl hybrid, Automatic 9-spd, AWD, gets 18 MPG, a gap of 5 MPG. With the file's assumptions that gap is worth about $1,000 a year in fuel.
| Version | Combined MPG | City MPG | Highway MPG | Annual fuel cost | CO2 g/mile | Electric range |
|---|---|---|---|---|---|---|
| S580e 4matic: 3.0 L, 6 cyl hybrid, Automatic 9-spd, AWD | 23 | 20 | 29 | $3,550 | 106 | 48 |
| AMG S63 E Performance: 4.0 L, 8 cyl hybrid, Automatic 9-spd, AWD | 18 | 15 | 23 | $4,550 | 305 | 16 |
Year by year
The Mercedes-Benz S-Class Plug-in hybrid is in the data for 4 of the 8 model years from 2019 to 2026. Its best combined rating is 23 MPG in both 2019 and 2025. The number of rated versions grew from 1 to 2.
| Model year | Versions | Best MPG | Lowest MPG | Fuel cost | CO2 g/mi | Class median |
|---|---|---|---|---|---|---|
| 2025 | 2 | 23 | 18 | $3,550 | 106 | 26.5 |
| 2023 | 1 | 23 | 23 | $3,550 | 379 | 23 |
| 2020 | 1 | 23 | 23 | $3,550 | 205 | 23 |
| 2019 | 1 | 23 | 23 | $3,550 | 205 | 23 |
Similar models
| Model | Powertrain | Combined MPG | Annual fuel cost | Model year |
|---|---|---|---|---|
| Porsche Panamera Plug-in hybrid | Plug-in hybrid | 21 | $3,900 | 2025 |
Rated almost identically and covered by this page:
- Audi A8 Plug-in hybrid 23 MPG, $3,550 a year, 1 version, last rated 2021
- Mercedes-Benz GLC-Class Plug-in hybrid 25 MPG, $3,300 a year, 3 versions, last rated 2025
Compare and rank
Rankings: Large cars.
Data: US EPA and DOE, as prepared in methods and data.